GC-MS Profiling and Antidandruff Potential of Eugenia aromatica Extracts
DOI:
https://doi.org/10.56919/usci.2543.025Keywords:
Eugenia aromatica, M. restricta, M globossa, S. epidermidis, P. acneAbstract
Dandruff, characterized by scalp flaking and itching, is associated with Malassezia, Staphylococcus, and Propionibacterium. This study aimed to evaluate the susceptibility of Eugenia aromatica (Clove) extracts against fungi, M. restricta and M globossa, and bacteria, S. epidermidis and P. acne. Plant extraction and GCSM analysis were carried out using a standard method; varying concentrations of 500, 700, and 100 mg/mL were prepared for Aqueous, Methanolic, Ethanolic, n-Hexane, and Chloroform extracts. Antimicrobial activity was assessed using the agar well. The ethanolic extract of E. aromatica showed the highest zones of inhibition at 1000mg/ml, with S. epidermidis showing 53 mm and P. acne showing 55 mm. M. restricta and M. globossa were more sensitive to the ethanolic extract of E. aromatica, with the highest zone of inhibition at 1000mg/ml, with M. restricta showing a 60 mm diameter and M. globossa demonstrating a 59 mm diameter. Fifty-one (51) Active compounds were identified using GC-MS analysis, including Eugenol (45.90%), cis-13-Octadecenoic acid (16.69%), Octadecanoic acid (6.93%), and n-Hexadecanoic acid (2.55%). These findings validate the traditional use of clove in herbal remedies for treating fungal and bacterial skin conditions. Future research should isolate these active compounds, test their synergistic effects, and evaluate their safety for therapeutic applications.
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