GC-MS Profiling and In Vitro Antifungal Efficacy of Vitellaria paradoxa Oil Against Dermatophytes and Yeasts

Authors

  • Zinat Mahmud Department of Microbiology, Federal University of Health Sciences, Azare Bauchi State Nigeria Author
  • Auwal Magaji Department of Microbiology, Sa'adu Zungur University Gadau, Bauchi State, Nigeria Author
  • Nathaniel Kwarau Luka Department of Microbiology, Sa'adu Zungur University Gadau, Bauchi State, Nigeria Author
  • Umar Bilyaminu Department of Microbiology, Sa'adu Zungur University Gadau, Bauchi State, Nigeria Author
  • Abdullahi Jibo Aliyu Department of Microbiology, Sa'adu Zungur University Gadau, Bauchi State, Nigeria Author
  • Abubakar Muhammad Zakariyya Department of Microbiology, Federal University of Dutsin-Ma Katsina State, Nigeria Author

DOI:

https://doi.org/10.56919/usci.2542.021

Keywords:

Vitellaria paradoxa, Natural, Antifungals, Fatty acids, Composition

Abstract

The rising concern of antifungal resistance has necessitated the exploration of natural alternatives.  This study investigated the in vitro antifungal efficacy of Vitellaria paradoxa oil against Candida albicans, Microsporum canis, and Trichophyton rubrum.  The oil's fatty acid composition was analyzed using gas chromatography.  The antifungal activity of the oil was evaluated using the agar well diffusion method, and all tests were conducted in triplicates.  The results showed that oleic acid (45.56%) and stearic acid (31.91%) were the predominant components of the oil.  The minimum inhibitory concentration (MIC) for all tested pathogens (Trichophyton rubrum, Candida albicans, and Microsporum canis) was 25% oil concentration.  The minimum fungicidal concentration (MFC) varied among species, with Trichophyton rubrum requiring 50% oil concentration, and Candida albicans and Microsporum canis requiring 100%.  Statistical analysis revealed no significant difference between the antifungal efficacy of 100% V. paradoxa oil and fluconazole (p = 0.627, F = 0.276).  These findings suggest that V. paradoxa oil has promising antifungal properties, warranting further clinical evaluation as a natural therapeutic alternative for fungal infections.

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Published

2025-06-30

Issue

Vol. 4 No. 2 (2025)

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How to Cite

Mahmud, Z., Magaji, A., Luka, N. K., Bilyaminu, U., Aliyu, A. J., & Zakariyya, A. M. (2025). GC-MS Profiling and In Vitro Antifungal Efficacy of Vitellaria paradoxa Oil Against Dermatophytes and Yeasts. UMYU Scientifica, 4(2), 200-205. https://doi.org/10.56919/usci.2542.021

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