Comparative Pulmonary Toxicity of PMS and Kerosene Fumes in a Rat Model
DOI:
https://doi.org/10.56919/usci.2652.007Keywords:
PMS, kerosene fumes, pulmonary histology, emphysema,, sub-chronic inhalationAbstract
This study investigated the sub-chronic effects of inhaled Premium Motor Spirit (PMS) and kerosene fumes on pulmonary histology and physiology in albino rats. Fifteen adult male rats were randomly assigned to three groups: control (fresh air), PMS-exposed, and kerosene-exposed. Exposures were conducted for six hours daily over five weeks. Body and lung weights were recorded, and histopathological analysis of lung tissues was performed using hematoxylin and eosin staining. Compared to controls (body weight: 203 ± 0.96 g; lung weight: 5.72 ± 0.63 g), both exposed groups showed significant reductions in body and lung weights. The kerosene-exposed group had a mean body weight of 137 ± 2.08 g and lung weight of 4.53 ± 0.56 g (p < 0.05), while the PMS-exposed group had a mean body weight of 145 ± 2.09 g and lung weight of 4.83 ± 0.58 g (p < 0.05). Histologically, controls exhibited normal lung architecture. Kerosene exposure resulted in mild inflammation, whereas PMS exposure caused severe emphysematous changes characterized by alveolar wall destruction and cystic space formation. These findings demonstrate that sub-chronic inhalation of PMS and kerosene fumes induces significant systemic and pulmonary toxicity, with PMS exerting more pronounced structural damage to lung tissue. The results highlight the potential respiratory health risks associated with chronic exposure to petroleum fumes, particularly in occupational and domestic settings with poor ventilation.
References
Adegoke, I. K., Adesoye, O. A., Iyagba, A. Y. S., & Adetoro, D. A. (2019). Determination of acetic and propanoic acids concentration in Nigerian kerosene. Journal of Engineering Studies and Research, 25(2), 7-14. DOI: https://doi.org/10.29081/jesr.v25i2.30
Adetona, O., Zhou, L., Smith, R. V., Sjodin, A., Hall, D. B., & Vena, J. E. (2021). Exposure to wood smoke and associated health effects in Sub-Saharan Africa. Environmental Science and Technology, 55(3), 1892-1901.
Adeyemi, T. A., Ogunbanjo, O. A., & Onikanni, A. A. (2021). Toxicological implications of petrol exposure on the respiratory system: A review. Toxicology Reports, 8, 1224-1231.
Agbonlahor, D. E., Igbokwe, N. A., & Aremu, A. O. (2018). Histological and biochemical alterations in the lungs of Wistar rats exposed to petrol and kerosene fumes. African Journal of Biomedical Research, 21(1), 45-52.
Ajarem, J. S., Ahmad, M., Maodaa, S. N., & Allam, A. A. (2021). Neurobehavioral and oxidative stress responses in rats exposed to gasoline vapors: Protective role of omega-3 fatty acids. Environmental Science and Pollution Research, 28(7), 8421-8431.
Ajayi, A. F., Komolafe, T. A., & Adepoju, O. A. (2020). Exposure to kerosene combustion products alters pulmonary surfactant and lung function in rats. Nigerian Journal of Physiology Sciences, 35(2), 85-91.
Alqahtani, M. S., Alqahtani, A. S., & Khatri, A. (2020). Lung health and gasoline vapors: A review of the impact of hydrocarbon exposure on respiratory function. Journal of Environmental and Public Health, 2020, Article 4835820.
Barrett, K. E., Barman, S. M., Brooks, H. L., & Yuan, J. X.-J. (2022). Ganong's review of medical physiology (27th ed.). McGraw Hill.
Brown, R. H., Suresh, V., & Tolaymat, L. (2021). Autonomic innervation of the lungs: Implications for asthma and pulmonary disease. Respiratory Medicine, 185, Article 106500. DOI: https://doi.org/10.1007/978-3-030-68688-8
Dantes, R., Smith, J., & Williams, P. (2016). Health effects associated with exposure to petroleum hydrocarbons and combustion products. Journal of Environmental Toxicology, 12(3), 145-158.
Ekong, M. B., Ekanem, T. B., & Akpantah, A. O. (2019). Effect of gasoline vapour inhalation on alveolar integrity in rats. Journal of Anatomy and Physiology, 9(1), 33-38.
Etzel, R. A., Balk, S. J., & American Academy of Pediatrics Council on Environmental Health. (2019). Ambient air pollution: Health hazards to children. Pediatrics, 143(6), Article e20192757. DOI: https://doi.org/10.1542/9781610022194
Ezekiel, O. G., Adepoju, F. G., & Ibrahim, A. T. (2019). Lung fibrosis induced by hydrocarbon inhalation in Wistar rats: A histopathological study. International Journal of Morphology, 37(2), 526-532.
Ezeokeke, C. T., Nwaopara, A. O., & Nnodim, J. K. (2018). Histopathological and oxidative stress effects of petrol fume inhalation on albino rats. International Journal of Pathology and Clinical Research, 4(2), 84-90.
Hathaway, G. J., & Proctor, N. H. (2014). Proctor and Hughes' chemical hazards of the workplace (5th ed.). Wiley-Blackwell.
Hayes, W. A., & Kruger, C. L. (2018). Inhalation toxicology. In Hayes' principles and methods of toxicology (6th ed.). CRC Press/Taylor and Francis.
Hiraiwa, K., & van Eeden, S. F. (2013). Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants. Mediators of Inflammation, 2013, 1-10. DOI: https://doi.org/10.1155/2013/619523
IARC. (2018). Monographs on the evaluation of carcinogenic risks to humans: Benzene (Vol. 120). International Agency for Research on Cancer.
Igboh, N. M., Gali, A. M., & Aliyu, M. M. (2001). Occupational exposure to petroleum products among automobile mechanics in Nigeria. Nigerian Journal of Clinical Practice, 4(2), 56-61.
ImmuONE. (2021). Inhalation toxicology. Retrieved from https://immuone.com/services/inhalation-toxicology/
Jiang, Y., Zhang, J., & Yang, L. (2020). The lung as a metabolic organ in health and disease. Cell Metabolism, 32(2), 221-232.
Jones, T. R., & Williams, D. A. (2015). Histopathological assessment of pulmonary tissues in inhalation toxicology studies. International Journal of Experimental Pathology, 96(4), 201-214.
Karia, R., Dehury, S., & Kumar, A. (2020). Hydrocarbon exposure: Respiratory health and other systemic effects. Indian Journal of Occupational and Environmental Medicine, 24(1), 13-19.
Kodidala, S. R., Prasad, K., & Rao, M. V. (2020). Chemical composition and toxicological implications of gasoline vapors. Environmental Health Review, 28(2), 89-102.
Kpemose, O. (2018). Analysis of Premium Motor Spirit (PMS) distributed in Lagos Metropolis, Nigeria. Retrieved from https://www.academia.edu/37493115/
McLaughlin, R. A., Gerth, D. J., & Trotter, M. J. (2021). Lymphatic drainage and immune response in the lung. Journal of Thoracic Disease, 13(3), 1358-1369. DOI: https://doi.org/10.21037/jtd-20-3072
Nieman, G. F., Satalin, J., Andrews, P., et al. (2020). Lung surfactant and alveolar mechanics. Critical Care Medicine, 48(10), 1472-1479.
Nwozor, K. K., Ezeugwu, H. C., & Ezeokonkwo, M. A. (2019). Oxidative stress and lung function changes following petrol fume exposure in rats. Journal of Environmental Health Research, 19(3), 12-20.
Olaniyan, A. M., Ogunyemi, O. M., & Olawuyi, T. S. (2022). Mitochondrial-mediated apoptosis in lungs of rats exposed to petroleum vapours. Toxicological Research, 38(1), 29-38.
Olusola, A. O., Fashina, O. M., & Ajiboye, E. A. (2020). Altered antioxidant defense in rats exposed to petroleum product fumes. Nigerian Journal of Biochemistry and Molecular Biology, 35(1), 67-74.
Oseni, O. A., Alabi, M. A., & Salami, A. T. (2021). Epigenetic modulation and DNA damage following sub-chronic exposure to benzene-containing hydrocarbons. Environmental Epigenetics, 7(1), Article dvab004.
Salem, H., & Katz, S. A. (2019). Inhalation toxicology (3rd ed.). CRC Press.
Smith, A. J., Brown, P. L., & Taylor, M. E. (2010). The albino rat as an experimental model for respiratory toxicology research. Laboratory Animal Research, 26(1), 15-22.
Standring, S. (Ed.). (2021). Gray's anatomy: The anatomical basis of clinical practice (42nd ed.). Elsevier.
Udonwa, N. E., Uko, E. K., Ikpeme, B. M., Ibanga, I. A., & Okon, B. O. (2019). Exposure of petrol station attendants and auto mechanics to Premium Motor Spirit fumes in Calabar, Nigeria. Journal of Environmental and Public Health, 2019, Article 281876.
Vogelmeier, C. F., Criner, G. J., Martinez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., Frith, P., Halpin, D. M. G., López Varela, M. V., Nishimura, M., Roche, N., Rodriguez-Roisin, R., Sin, D. D., Singh, D., Stockley, R., ... Agustí, A. (2017). Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. American Journal of Respiratory and Critical Care Medicine, 195(5), 557-582. DOI: https://doi.org/10.1164/rccm.201701-0218PP
Wang, Y., Liu, Y., Zhang, J., & Li, Y. (2019). The mucociliary clearance system of the respiratory tract: Mechanisms and clinical significance. International Journal of Molecular Sciences, 20(10), Article 2431.
West, J. B., & Luks, A. M. (2022). West's respiratory physiology: The essentials (11th ed.). Wolters Kluwer.
Wolfreys, A., Kilgour, J., Allen, A. D., Dudal, S., Freke, M., Jones, D., ... & Robinson, I. (2021). Review of the technical, toxicological, and PKPD considerations for conducting inhalation toxicity studies on biologic pharmaceuticals—The outcome of a cross-industry working group survey. Toxicologic Pathology, 49(2), 403-417. DOI: https://doi.org/10.1177/0192623321988841
Zhang, Q., Hang, J., Wang, X., Xu, Z., & Chen, W. (2021). Emerging technologies for in vitro inhalation toxicology. Advanced Healthcare Materials, 10(15), Article 2100380. DOI: https://doi.org/10.1002/adhm.202100633
Zhang, W., Jin, Y., & Xu, Q. (2022). Prenatal exposure to ambient air pollution and birth outcomes: A systematic review and meta-analysis. Environmental Research, 204, Article 112024.
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