Ameliorating the Effects of Trypanosoma Evansi Infection in Wistar Rats Using Selected Nutraceuticals, Ethidium Bromide and Ethidium Chloride
DOI:
https://doi.org/10.56919/usci.2544.019Keywords:
Trypanosomiasis, Nutraceuticals, Wistar rats, Trypanosoma evansi, Ethidium bromide, Ethidium chlorideAbstract
African Trypanosomiasis is a disease that affects humans and animals, caused by trypanosomes in sub-Saharan Africa, despite decades of vector control and treatments. The disease remains endemic and an impediment to socio-economic development. 45 male Wistar rats were purchased from the animal colony of the Nigerian Institute for Trypanosomiasis Research (NITR) and divided into 9 groups of 5 rats each. Group I, (uninfected, untreated), Group II (Infected, untreated), while Groups III, IV, V, VI, VII, VIII and IX were the groups tested. Each rats were infected with 1× 105 Trypanosomes and treated with 6.43 mg/kg Glucosamine (Group III), 24.6 mg/kg Omega-H3 (Group IV), 1 mg/kg Ethidium bromide (Group V), 1 mg/kg Ethidium chloride (Group VI), Group VII were treated with Ethidium bromide and Glucosamine, Group VIII were treated with Ethidium chloride and Omega H3, while Group IX was treated with both of the nutraceuticals for 7 days. PCV, body temperature, and body weight were also determined. Results showed that PCV was significantly reduced (P < 0.05) in the infected and treated groups compared to group I, and was greater in group II. No significant (P > 0.05) difference was observed between the groups treated with the Nutraceuticals and the Trypanocides. Body temperature increased in all groups compared with group I and was highly significant (P < 0.05) in group II. No significant (P < 0.05) increase in body weight of rats was observed in the groups treated compared to group II, but a decrease in body weight was observed in all groups compared to group I. No difference observed in groups treated with Nutraceuticals and the Trypanocides. Nutraceuticals have ameliorated the effects of Trypanosoma evansi infection on PCV, body temperature, and body weight in Wistar rats.
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